干眼新型干预手段的研究主要集中在维持眼表微环境平衡,包括对抗炎症方面的降低炎性因子表达和新型的损伤相关分子模式,对抗氧化应激方面的维持氧化酶和抗氧化酶平衡和激活内质网应激反应,以及通过增加黏蛋白、脂质含量维持泪膜稳定性三个方面.
The study of new intervention methods on dry eye mainly focuses on maintaining the balance of ocular surface microenvironment,primarily including the following three aspects.(1) Anti-inflammation such as reducing the expression of inflammation factors and damage-associated molecular patterns (DAMPs).(2)Anti-oxidation such as maintaining the balance between oxidase and antioxidant enzymes and activing endoplasmic reticulum stress.(3) Maintaining stability of tear film by increasing the content of mucin and lipid.