目的 探讨异丙托溴铵与复方异丙托溴铵对慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭患者的肺功能及动脉血气分析的影响.方法 选取 2021 年1 月—2022 年12月我院收治的 80 例AECOPD合并呼吸衰竭患者为研究对象,按患者采取的治疗方案不同将其分为对照组和观察组,各40 例.对照组行无创呼吸机联合异丙托溴铵治疗,观察组行无创呼吸机联合复方异丙托溴铵治疗.比较两组症状改善情况、肺功能、动脉血气分析指标及不良反应发生情况.结果 治疗后,观察组改良英国医学研究委员会呼吸困难量表分级优于对照组,差异有统计学意义(P<0.05).治疗后,观察组第 1 秒用力呼气容积占预计值百分比高于对照组,呼气峰值流速快于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组血氧饱和度高于对照组,差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论 无创呼吸机联合复方异丙托溴铵能缓解AECOPD合并呼吸衰竭患者的呼吸困难症状、改善患者肺功能和动脉血气指标.
Objective To investigate the effects of ipratropium bromide and compound ipratropium bromide on pulmonary function and arterial blood gas analysis in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with respiratory failure.Methods 80 AECOPD patients with respiratory failure admitted to our hospital from January 2021 to December 2022 were selected as the research subjects.They were divided into a control group and an observation group based on the different treatment plans adopted by the patients,with 40 cases in each group.Both groups were treated with non-invasive ventilators,the control group was treated with combined ipratropium bromide,and the observation group was treated with combined compound ipratropium bromide.Improvement of symptoms,lung function,arterial blood gas analysis indexes and adverse reactions were compared between the two groups.Results After treatment,the modified British Medical Research Council Respiratory Difficulty Scale classification of the observation group was better than that of the control group,with a statistically significant difference(P<0.05).After treatment,the percentage of forced expiratory volume in the observation group at the first second was higher than those in the control group,and the peak expiratory flow rate was faster than the control group,with statistically significant differences between the groups(P<0.05).After treatment,the blood oxygen saturation in the observation group was higher than that in the control group,with a statistically significant difference(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Non-invasive ventilator combined with compound ipratropium bromide relieves dyspnoea symptoms and improves lung function and arterial blood gas indices in patients with AECOPD combined with respiratory failure.