In Reply.— Dr Steffen has raised several important points in his letter. We concur that the term adenoma sebaceum reflects more historical interest than histological accuracy. Angiofibroma is the more appropriate term. While Dr Steffen indicates that we "claim that the [sic] adenoma sebaceum and periungual fibromas (ie, angiofibromas) are diagnostic of the tuberous sclerosis complex," we actually made no such specific statement ourselves but referred to the diagnostic criteria for tuberous sclerosis established and published by Gomez,1 which are the accepted standards. While these diagnostic criteria of Gomez may be viewed as arbitrary and subject to further studies for better definition, none of our probands had equivocal findings. All had involvement of at least two major organ systems; therefore, none had only angiofibromas or periungual fibromas. Similarly, all but one of the four previously unsuspected heterozygous parents had involvement of two or more organ systems. The only