Protein synthesis in muscles from normal and dystrophic hamsters
- Resource Type
- Authors
- D M Nicholls; M Saleem
- Source
- The Biochemical journal. 180(1)
- Subject
- medicine.medical_specialty
Cell-Free System
Age Factors
Peptide Chain Elongation, Translational
Brain
Muscle Proteins
Cell Biology
Biology
In Vitro Techniques
Muscular Dystrophy, Animal
RNA, Transfer, Amino Acyl
Biochemistry
Rats
Endocrinology
Liver
Internal medicine
Cricetinae
medicine
Protein biosynthesis
Animals
Molecular Biology
Research Article
- Language
- ISSN
- 0264-6021
Homogenates of hindleg muscle were obtained from control and dystrophic male hamsters, 30 and 190 days of age, and were used to prepare the postmicrosomal pH5-supernatant fraction. The activity of this fraction in the incorporation of [14C]phenylalanyl-tRNA into peptides was increased in the dystrophic-muscle preparations. No such increase was found in brain or liver preparations from dystrophic hamsters. The increased capacity for aminoacyl-tRNA binding that was observed in preparations from dystrophic animals is discussed.