AA amyloidosis in psoriatic arthritis
- Resource Type
- Authors
- Anthony Dorman; Paul O'Connell; J. G. Ryan
- Source
- Irish Journal of Medical Science. 175:81-82
- Subject
- Adult
Male
medicine.medical_specialty
Poor prognosis
Nephrotic Syndrome
medicine.medical_treatment
Disease
urologic and male genital diseases
Renal amyloidosis
Psoriatic arthritis
AA amyloidosis
medicine
Humans
business.industry
Amyloidosis
Arthritis, Psoriatic
Immunosuppression
General Medicine
medicine.disease
Dermatology
Cyclosporine
Cardiomyopathies
Complication
business
Immunosuppressive Agents
- Language
- ISSN
- 1863-4362
0021-1265
Amyloidosis is an extremely rare complication of psoriatic arthritis (PsA) and is associated with a poor prognosis. We report a case of amyloidosis secondary to severe PsA in a young patient and the course of his disease over a 13-year period of aggressive immunosuppression.Diagnosis of renal amyloidosis was made on biopsy: multi-agent immunosuppressive therapy was continued with stabilisation of renal function.Marked deterioration in renal function subsequently occurred following a reduction in cyclosporin A (CyA) dose and repeat biopsy confirmed worsening amyloidosis.This case report emphasises the need for aggressive control of the inflammatory response in secondary amyloidosis.