GOLPH3, a good prognostic indicator in early-stage NSCLC related to tumor angiogenesis
- Resource Type
- Authors
- Shuhai Li; Yu Tian; Cun Gao; Hui Tian; Ming Lu; Weiming Yue; Lei Qi; Wensi Hu; Lin Li; Libo Si
- Source
- Asian Pacific journal of cancer prevention : APJCP. 15(14)
- Subject
- Oncology
Male
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Epidemiology
Angiogenesis
Antigens, CD34
Biology
Neovascularization
Antigen
Internal medicine
Carcinoma, Non-Small-Cell Lung
medicine
Carcinoma
Biomarkers, Tumor
Humans
Stage (cooking)
Aged
Regulation of gene expression
Neovascularization, Pathologic
TOR Serine-Threonine Kinases
Public Health, Environmental and Occupational Health
Endothelial Cells
Membrane Proteins
medicine.disease
Prognosis
Gene Expression Regulation, Neoplastic
Tumor progression
Microvessels
Disease Progression
Immunohistochemistry
Female
medicine.symptom
- Language
- ISSN
- 2476-762X
Background: Golgi phosphoprotein-3 (GOLPH3) is implicated in cancer development and progression. The aim of this study was to evaluate the prognostic significance of GOLPH3 protein and its association with tumor angiogenesis in patients with early-stage NSCLC. Materials and Methods: Immunohistochemistry was performed to determine GOLPH3 protein expression and allow assessment of intratumoral microvessel density (MVD) by counting CD-34 positive immunostained endothelial cells. Correlations of expression with MVD, clinicopathologic features and clinical prognosis were analyzed. Results: A notably higher level of GOLPH3 expression was found in early-stage NSCC tissues at the protein level. However, we do not find any correlation between GOLPH3 expression and clinicopathologic features (p>0.05), although higher MVD was positively associated with GOLPH3 overexpression (p