Effects of low doses of chlormadinone acetate in the rat
- Resource Type
- Authors
- Madan Mohan Sharma; G. Lal; D. Jacob
- Source
- Reproduction. 48:177-179
- Subject
- Male
endocrine system
Embryology
medicine.medical_specialty
Pituitary gland
Chlormadinone Acetate
Genitalia, Male
Biology
Andrology
chemistry.chemical_compound
Chlormadinone acetate
Endocrinology
Internal medicine
medicine
Animals
Endocrine system
Spermatogenesis
Cholesterol
Obstetrics and Gynecology
Fructose
Organ Size
Cell Biology
Epididymis
Rats
medicine.anatomical_structure
Reproductive Medicine
chemistry
Pituitary Gland
Hormone
- Language
- ISSN
- 1741-7899
1470-1626
The effects of chlormadinone acetate (CA) administered im in doses of .2-1 mb/day for 40 days on the reproductive organs and pituitary gland of the rat were studied. The .2 mg/day regimen did not produce changes markedly different from control values. However as the dosage increased there was a parallel decrease in the weights of the testis accessory sex organs and the pituitary. Pituitary gonadotropin function and the fructose content of the coagulating gland also decreased while testicular levels of cholesterol increased. Spermatogenesis was arrested in animals receiving .5 or 1 mg/day CA and no spermatozoa were observed in the epididymis of these animals. Immotile spermatozoa were found in the epididymides of rats receiving .2 mg/day. The results indicate that CA is capable of selectively hindering epididymal function and maturation of spermatozoa at low doses without markedly altering pituitary gonadotropin secretion or testicular function.