Complement-endothelial cell interactions: pathophysiological implications
- Resource Type
- Authors
- M. R. Daha; Fabio Fischetti; Aldo Dobrina; M. Pausa; Robert B. Sim; Francesco Tedesco
- Source
- Molecular Immunology. 36:261-268
- Subject
- immunology, Complement System Protein
Xenotransplantation
medicine.medical_treatment
Immunology
Ischemia
cytology/immunology/physiopathology
Inflammation
Cell Communication
Biology
Animals, Cell Communication
immunology, Complement System Proteins
physiology, Endothelium
Vascular
cytology/immunology/physiopathology, Humans
Mole
medicine
Animals
Humans
complement
Endothelium
Molecular Biology
business.industry
Complement System Proteins
medicine.disease
Pathophysiology
Complement (complexity)
Complement system
Cell biology
Endothelial stem cell
Coagulation
physiology
Endothelium, Vascular
medicine.symptom
business
Function (biology)
- Language
- ISSN
- 0161-5890
The function of the endothelial cells can be modulated by humoral factors present in the circulation and in the extravascular fluid, including proteins of the complement system. This review examines the multiple interactions between the complement system and the endothelial cells and their functional consequences on inflammation, coagulation and regulation of vascular tone. The implications of these interactions in the induction and progression of the vascular lesions occurring in atherosclerosis, ischemia/reperfusion and xenotransplantation and the possible therapeutic approaches in terms of complement regulation are also discussed.