Relationships Between Spatial Contrast Sensitivity and Parafoveal Cone Density in Normal Subjects and Patients With Retinal Degeneration
- Resource Type
- Authors
- Takashi Fujikado; Tomomitsu Miyoshi; Takeshi Morimoto; Hiroyuki Kanda; Takao Endo; Suguru Miyagawa; Tibor Karl Lohmann; Masakazu Hirota
- Source
- Ophthalmic Surgery, Lasers and Imaging Retina. 48:106-113
- Subject
- Adult
Male
Retinal degeneration
Fovea Centralis
medicine.medical_specialty
Adolescent
genetic structures
Scanning laser ophthalmoscope
Fundus Oculi
Cell Count
Contrast Sensitivity
Young Adult
03 medical and health sciences
0302 clinical medicine
Ophthalmology
medicine
Humans
Fluorescein Angiography
Child
Retina
business.industry
Retinal Degeneration
Mean age
Spatial contrast
Middle Aged
medicine.disease
Ophthalmoscopy
medicine.anatomical_structure
Healthy individuals
Retinal Cone Photoreceptor Cells
030221 ophthalmology & optometry
Optometry
Female
business
Cone mosaic
Tomography, Optical Coherence
030217 neurology & neurosurgery
- Language
- ISSN
- 2325-8179
2325-8160
BACKGROUND AND OBJECTIVE: To investigate the relationship between spatial contrast sensitivity (CS) and parafoveal cone density (PCD). PATIENTS AND METHODS: Fifteen healthy individuals (mean age: 26.1 years ± 4.5 years) and nine patients with hereditary retinal degeneration (mean age: 31.6 years ± 13.4 years) without media opacities were studied. The CS was measured by CSV-1000 (VectorVision, Greenville, OH). The cone mosaic was photographed with an adaptive optics scanning laser ophthalmoscope (AOSLO) with a 1° × 1° field of view centered on the fovea. The PCD was calculated in an annular area with radii of 0.38° and 0.43°. The CS was converted to the logarithm (logCS), and the area under the logCS function (AULCSF) was determined. RESULTS: The AULCSF was significantly and positively correlated with the PCD in the control (R 2 = 0.522; P = .003) and retinal degeneration (R 2 = 0.514; P = .03) groups. CONCLUSION: PCD can predict the spatial contrast sensitivity in normal subjects or patients with retinal degeneration without media opacities. [ Ophthalmic Surg Lasers Imaging Retina . 2017;48:106–113.]