Thiol Modification of Psyllium Husk Mucilage and Evaluation of Its Mucoadhesive Applications
- Resource Type
- Authors
- Munish Ahuja; Meenakshi Bhatia
- Source
- The Scientific World Journal, Vol 2013 (2013)
The Scientific World Journal
- Subject
- food.ingredient
Article Subject
Polymers
lcsh:Medicine
lcsh:Technology
Psyllium
General Biochemistry, Genetics and Molecular Biology
chemistry.chemical_compound
Crystallinity
food
Adhesives
medicine
Organic chemistry
Sulfhydryl Compounds
Thioglycolic acid
lcsh:Science
General Environmental Science
chemistry.chemical_classification
Mucous Membrane
Psyllium Husk
Viscosity
lcsh:T
lcsh:R
General Medicine
Polymer
Kinetics
chemistry
Thiol
Surface modification
lcsh:Q
Swelling
medicine.symptom
Gels
Research Article
Nuclear chemistry
- Language
- ISSN
- 1537-744X
Thiol functionalization of psyllium was carried out to enhance its mucoadhesive potential. Thiolation of psyllium was achieved by esterification with thioglycolic acid. Thiolation was observed to change the surface morphology of psyllium from fibrous to granular and result in a slight increase in the crystallinity and swelling. Thiolated psyllium was found to contain 3.282 m moles of thiol groups/g of the polymer. Mucoadhesive applications of thiolated psylium were explored by formulating gels using metronidazole as the model drug. On comparative evaluation thiolated psyllium gels showed 3-fold higher mucoadhesive strength than the psyllium gels as determined by modified physical balance using chicken buccal pouch. The results ofin vitrorelease study revealed that thiolated psyllium gels provided a prolonged release of metronidazole. Further, the psyllium and thiolated psyllium gels were found to release the drug following first-order kinetics by combination of polymer relaxation and diffusion through the matrix.