Naringin Alleviates Atherosclerosis in ApoE
- Resource Type
- Authors
- Feng, Wang; Chengying, Zhao; Guifang, Tian; Xue, Wei; Zihan, Ma; Jiefen, Cui; Rujun, Wei; Yuming, Bao; Wei, Kong; Jinkai, Zheng
- Source
- Journal of agricultural and food chemistry. 68(45)
- Subject
- Mice, Knockout
Atherosclerosis
Gastrointestinal Microbiome
Fibroblast Growth Factors
Mice
Apolipoproteins E
Cholesterol
Liver
Flavanones
Animals
Humans
Female
Proprotein Convertase 9
Cholesterol 7-alpha-Hydroxylase
- Language
- ISSN
- 1520-5118
Naringin, a major flavonoid in citrus, has potential for preventing atherosclerosis. The presence in the colon of a large amount of naringin after oral intake might affect the gut microbiota. We investigated the role of gut microbiota remodeling in the alleviation of atherosclerosis by naringin. Naringin significantly alleviated atherosclerosis and lowered the serum and liver cholesterol levels by 24.04 and 28.37% in ApoE