The Supplementary information file contains: (i) Supplementary Methods, concerning PCR primers, antibodies and explanation of the chemometric approach. (ii) Supplementary Figures 1-4, which provide extended data for the multivariable models of Figure 2 and 3, MS/MS analyses, and further gene expression data supporting Figure 5. (iii) Supplementary Tables 1-4, which provide demographics of the cohorts and univariate lipid analyses from Cohort 1 and 2.