Additional file 1. Table S1. Elimination half-life of each antipsychotic. Table S2. Ninth and 10th revision international classification of diseases codes of comorbidity. Table S3. List of comedications in the presented study. Table S4. Receptor-binding profile of antipsychotics with bronchial relaxation effect. Table S5. The adjusted odds ratio of all covariates in multivariable conditional logistic regression. Table S6. Risk of severe asthma exacerbation by different classes of antipsychotics and doses in patients with schizophrenia. Table S7. Risk of severe asthma exacerbation by different classes of antipsychotics and doses in patients with depression. Table S8. Risk of severe asthma exacerbation by different classes of antipsychotics and doses in patients with bipolar disorder. Table S9. Risk of severe asthma exacerbation by different classes of antipsychotics and doses after excluding patients had psychiatric disorder related admission or ED visiting. Table S10. Risk of severe asthma exacerbation by different classes of antidepressants and doses.