Metal-free syntheses of oxindole derivatives via a benzoylation/substitution/desulfonylation/cyclization cascade
- Resource Type
- Authors
- Ping Xie; Yang Zhou; Ben Niu; Zhaogang Bian; Aihua Zhou; Wannian Zhao; Charles U. Pittman
- Source
- RSC Adv.. 4:43525-43528
- Subject
- chemistry.chemical_compound
chemistry
Cascade reaction
Metal free
Cascade
organic chemicals
General Chemical Engineering
Substitution (logic)
Organic chemistry
Oxindole
General Chemistry
Metal catalyst
- Language
- ISSN
- 2046-2069
A benzoylation/substitution/desulfonylation/cyclization cascade reaction giving oxindole derivatives was discovered. The reaction used aromatic aldehydes and N-alkyl-N-(phenylsulfonyl)methacrylamides as starting materials, and proceeded under mild conditions without using toxic metal catalysts. 3-Methyl-3-aroyloxindole derivatives were formed in good yields.