The effects of rutin on the development of pentylenetetrazole kindling and memory retrieval in rats
- Resource Type
- Authors
- Seyed-Reza Mortazavi; Freshteh Safdari; Fatemeh Samiee-Rad; Sepideh Saroukhani; Amir-Abdollah Zangivand; Esmail Abbasi; Marjan Nassiri-Asl
- Source
- Epilepsy & Behavior. 18:50-53
- Subject
- Male
Synthetic derivatives
Rutin
Flavonoid
Pharmacology
Behavioral Neuroscience
Epilepsy
chemistry.chemical_compound
Seizures
Avoidance Learning
Kindling, Neurologic
medicine
Animals
Rats, Wistar
chemistry.chemical_classification
Analysis of Variance
Kindling
Dietary constituent
Retention, Psychology
medicine.disease
Rats
Neurology
chemistry
Anesthesia
Pentylenetetrazole
Neurology (clinical)
Analysis of variance
Passive avoidance
Psychology
- Language
- ISSN
- 1525-5050
Individuals with epilepsy often complain about memory deficits. Various synthetic derivatives of natural flavonoids are known to have neuroactive properties. Rutin is a flavonoid that is an important dietary constituent of foods and plant-based beverages. The aim of the present study was to investigate the effects of rutin on memory retrieval in pentylenetetrazole (PTZ)-kindled rats using a step-through passive avoidance task. We administered rutin and PTZ intraperitoneally every other day prior to the start of training. Two retention tests were subsequently performed to assess memory in these rats. The results suggest that pretreatment with rutin at 50 and 100mg/kg can attenuate seizure severity during the kindling procedure. Furthermore, rutin administration significantly increased the step-through latency in the passive avoidance paradigm. Taken together, these results indicate that rutin has a potential role in enhancing memory retrieval in kindled rats.