Control of S phase duration: a replication capacity model with E2F transcription at its heart
- Resource Type
- Authors
- Robertus A.M. de Bruin; Cosetta Bertoli
- Source
- Molecular & Cellular Oncology
article-version (VoR) Version of Record
- Subject
- 0303 health sciences
Cancer Research
DNA replication
S phase
Biology
Genome
Replication (computing)
Cell biology
Phase duration
03 medical and health sciences
DNA replication capacity
0302 clinical medicine
Transcription (biology)
030220 oncology & carcinogenesis
Gene duplication
Author’s Views
Molecular Medicine
E2F-dependent transcription
E2F
genome stability
Article Commentary
030304 developmental biology
Genome stability
- Language
- ISSN
- 2372-3556
DNA replication capacity, the maximal amount of DNA a cell can synthesize at any given time during S phase, is controlled by E2F-dependent transcription. Controlling replication capacity limits the replication rate and provides a robust mechanism to keep replication fork speed within an optimal range whilst ensuring timely completion of genome duplication.