Soluble CD14 levels are increased and inversely correlated with the levels of hepatitis B surface antigen in chronic hepatitis B patients
- Resource Type
- Authors
- Helmut M. Diepolder; Sophia Steyaert; Peter Vanlandschoot; Geert Leroux-Roels; Hans Van Vlierberghe
- Source
- Ghent University Academic Bibliography
- Subject
- Adult
Lipopolysaccharides
Liver Cirrhosis
HBsAg
Adolescent
Lipopolysaccharide Receptors
medicine.disease_cause
Hepatitis B, Chronic
Orthohepadnavirus
Virology
Humans
Medicine
Aged
Hepatitis B virus
Hepatitis B Surface Antigens
Membrane Glycoproteins
biology
business.industry
C-reactive protein
Hepatitis C, Chronic
Middle Aged
Hepatitis B
biology.organism_classification
medicine.disease
Lipopolysaccharide binding
C-Reactive Protein
Infectious Diseases
Hepadnaviridae
Immunology
biology.protein
Carrier Proteins
business
Lipopolysaccharide binding protein
Acute-Phase Proteins
- Language
- ISSN
- 1096-9071
0146-6615
Because it was observed recently that yeast-derived recombinant HBsAg interacts in a lipopolysaccharide binding protein-dependent manner with CD14 expressed on human monocytes, we investigated whether HBsAg influences the serum levels of sCD14, lipopolysaccharide binding protein and C-reactive protein in hepatitis B patients. Samples from acute and chronic hepatitis B and chronic hepatitis C patients were tested. All analytes were measured using commercial assays. HBsAg was quantified using an NIBSC titrated standard. sCD14 levels were higher in chronic hepatitis B and C patients than in healthy controls (P = 0.0006 and P