This paper explores and analyzes the capital structure determinants of chemical sector of Pakistan. The sample is comprises over 34 listed chemical companies of Pakistan. All companies are listed at Pakistan’s national stock exchange “Karachi Stock Exchange (KSE). Debt/Equity is taken as dependent variable and five independent variables are Profitability, Growth, Financial Cost, Size, and Tangibility. The Results showed that financial cost and tangibility are positively related while other variables have negative relationship with the dependent variable (Debt/Equity).