Effect of GDNF on Morphology, Proliferation, and Phagocytic Activity of Rat Neonatal Cortex Isolated Microglia
- Resource Type
- Authors
- Albert A. Rizvanov; Margarita N. Zhuravleva; Yana O. Mukhamedshina
- Source
- BioNanoScience. 6:379-383
- Subject
- 0301 basic medicine
Microglia
biology
urogenital system
Nervous tissue
Central nervous system
Biomedical Engineering
Bioengineering
Neuroprotection
Cell biology
Pathogenesis
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
nervous system
Neurotrophic factors
Immunology
medicine
Glial cell line-derived neurotrophic factor
biology.protein
030217 neurology & neurosurgery
Neuroinflammation
- Language
- ISSN
- 2191-1649
2191-1630
Microglia are the main defenders of the central nervous system and at the same time are involved in the pathogenesis of various neurological disorders. Microglia hyperactivity or phagocytic impairment exacerbates degenerative processes in nervous tissue leading to further loss of function. A variety of factors and cytokines may modify microglia function. In our study, it was shown that glial cell line-derived neurotrophic factor (GDNF), a well-known neuroprotective molecule, decreases phagocytic activity of microglia in vitro model of spinal cord injury. Recombinant adenovirus encoding GDNF (Ad5-GDNF) transfected microglia have shown the same effect and can be potentially used as a therapeutic agent in case of neurotrauma due to its debris phagocytic and GDNF-associated neuroprotective role.