SKLB-14b, a novel oral microtubule-destabilizing agent based on hydroxamic acid with potent anti-tumor and anti-multidrug resistance activities
- Resource Type
- Authors
- Wanhua, Zhang; Linyu, Yang; Wenting, Si; Minghai, Tang; Peng, Bai; Zejiang, Zhu; Shuang, Kuang; Jiang, Liu; Mingsong, Shi; Jinxing, Huang; Xuanming, Chen; Dan, Li; Yi, Wen; Zhuang, Yang; Kai, Xiao; Lijuan, Chen
- Source
- Bioorganic Chemistry. 128:106053
- Subject
- Ovarian Neoplasms
Lung Neoplasms
Organic Chemistry
Antineoplastic Agents
Apoptosis
Hydroxamic Acids
Microtubules
Xenograft Model Antitumor Assays
Biochemistry
Tubulin Modulators
Mice
Tubulin
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Drug Discovery
Animals
Humans
Female
Molecular Biology
Cell Proliferation
- Language
- ISSN
- 0045-2068
A hydroxamic acid based microtubule-destabilizing agent (MDA) SKLB-14b was discovered in this study, which was derived from shortening the linker length of the HDAC6 and microtubule dual-target inhibitor SKLB-23bb. SKLB-14b exhibited low nanomolar IC