Transfusion-related acute lung injury (TRALI) following autologous stem cell transplant for relapsed acute myeloid leukaemia: a case report and review of the literature
- Resource Type
- Authors
- Lucas; Jones; Vora; Leach
- Source
- Transfusion medicine (Oxford, England). 8(4)
- Subject
- Male
Lung injury
Leukemia, Myelomonocytic, Acute
Full recovery
HLA-A2 Antigen
medicine
Humans
Platelet concentrate
Bronchiolitis Obliterans
Lung
biology
business.industry
Hematopoietic Stem Cell Transplantation
Hematology
medicine.disease
Pathophysiology
Child, Preschool
Immunology
Acute Disease
Chronic Disease
biology.protein
Myeloid leukaemia
Stem cell
Antibody
business
Lung Diseases, Interstitial
Transfusion-related acute lung injury
- Language
- ISSN
- 0958-7578
A fatal case of transfusion-related acute lung injury (TRALI) in a child post-autologous stem cell transplant for relapsed acute myeloid leukaemia is described. The implicated product was a single unit platelet concentrate containing anti-HLA A2 and granulocyte-specific anti-NA1 antibodies. The recipient typed as HLA A2/A2, NA1/NA1. This is the first reported case of TRALI following a transplant procedure for a haematological condition. It is also unusual in that the patient failed to make a full recovery and that two relevant leucocyte antibodies of clear specificity were identified in the donor plasma. The literature relating to the pathophysiology, clinical sequelae and management of TRALI is reviewed.