Structure of Rat Testicles after Intravenous Injection of Nanosized Magnetite Particles
- Resource Type
- Authors
- I. V. Sukhodolo; V. Yu. Usov; I. V. Mil’to; V. V. Ivanova
- Source
- Bulletin of Experimental Biology and Medicine. 166:680-685
- Subject
- Male
0301 basic medicine
Radiochemistry
Connective tissue
General Medicine
General Biochemistry, Genetics and Molecular Biology
Rats
03 medical and health sciences
Magnetite Nanoparticles
chemistry.chemical_compound
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
chemistry
Injections, Intravenous
Testis
Magnetic nanospheres
medicine
Animals
Nanospheres
030217 neurology & neurosurgery
Magnetite
- Language
- ISSN
- 1573-8221
0007-4888
The structure of the testicles was studied in adult rats in 120 days after a single intravenous injection of chitosan-modified (magnetic nanospheres) and lipid-modified (magnetoliposomes) nanosized magnetite particles. Perls histochemical reaction detected in the testicular interstitial connective tissue the cells which absorbed and accumulated magnetite nanoparticles. The dynamics of spermatogenesis index and the count of Perls+ cells in the rat testicles were traced throughout the experiment. The studied modified nanosized magnetite particles did not penetrate through the blood-testicle barrier in rats.