Polymorphisms of SLC11A1(NRAMP1) rs17235409 associated with and susceptibility to spinal tuberculosis in a southern Han Chinese population
- Resource Type
- Authors
- Tao, Li; Longjie, Wang; Chaofeng, Guo; Hongqi, Zhang; Peng, Xu; Shaohua, Liu; Xiaojiang, Hu; Qile, Gao
- Source
- Infection, Genetics and Evolution. 98:105202
- Subject
- Adult
Male
Microbiology (medical)
Middle Aged
Polymorphism, Single Nucleotide
Microbiology
Infectious Diseases
Asian People
Genetics
Humans
Female
Genetic Predisposition to Disease
Tuberculosis, Spinal
Cation Transport Proteins
Molecular Biology
Ecology, Evolution, Behavior and Systematics
- Language
- ISSN
- 1567-1348
To investigate the association between SLC11A1 (NRAMP1) rs17235409 (D543N) polymorphisms and susceptibility to spinal tuberculosis (STB) in the Han population in southern China.This study included 227 STB patients and 516 controls. Polymorphisms of SLC11A1 rs17235409 were genotyped using a SNPscan™ kit, and the protein was detected by western blotting.The genotype and allele frequency distributions of SLC11A1 rs17235409 differed significantly between the STB group and the control group(χVariant genotypes at the rs17235409 locus of the SLC11A1 gene are associated with STB in the southern Han Chinese population. NRAMP1 protein expression is increased in patients with spinal tuberculosis, and the presence of the A allele increases the risk of developing STB.