A dendritic-cell brake on antitumour immunity
- Resource Type
- Authors
- Hélène Salmon; Miriam Merad
- Source
- Subject
- Multidisciplinary
XBP1
endocrine system diseases
Cancer
Dendritic cell
Biology
medicine.disease
DNA-binding protein
Article
Immune system
Cellular stress response
Immunology
Cancer research
medicine
Ovarian cancer
Transcription factor
- Language
- English
Activation of a cellular stress response and the transcription factor XBP1 in dendritic cells has now been shown to limit the cells' ability to stimulate antitumour immune responses in a mouse model of ovarian cancer.