High XBP1 expression is a marker of better outcome in multiple myeloma patients treated with bortezomib
- Resource Type
- Authors
- Gambella, Manuela; Rocci, Alberto; Passera, Roberto; Gay, Francesca; Omedè, Paola; Crippa, Claudia; Corradini, Paolo; Romano, Alessandra; Rossi, Davide; Ladetto, Marco; Boccadoro, Mario; Palumbo, Antonio
- Source
- Subject
- Male
X-Box Binding Protein 1
XBP1
Myeloma protein
Antineoplastic Agents
Regulatory Factor X Transcription Factors
Biology
Disease-Free Survival
BLIMP1
Bortezomib
IRF4
medicine
Biomarkers, Tumor
Humans
Letters to the Editor
Transcription factor
Multiple myeloma
Aged
Neoplastic
Tumor
Hematology
medicine.disease
Molecular biology
Boronic Acids
Neoplasm Proteins
DNA-Binding Proteins
Gene Expression Regulation, Neoplastic
Survival Rate
medicine.anatomical_structure
Gene Expression Regulation
multiple myeloma biomarker
Pyrazines
Monoclonal
Cancer research
Female
Bone marrow
Multiple Myeloma
Biomarkers
medicine.drug
Transcription Factors
- Language
- English
Multiple myeloma (MM) is a hematologic tumor characterized by accumulation of monoclonal plasma cells (PCs) in the bone marrow (BM) producing antigen-specific immunoglobulins. The transcription factor X box binding protein 1 (XBP1), the interferon regulatory factor 4 (IRF4) and the transcriptional