High-molecular weight polyoxyethylene as an additive in ophthalmic solutions
- Resource Type
- Authors
- Evgeni Minkov; Stefka Mihailova; Svetla Bogdanova; Nevena Manolova; Ilia Raschkov; Maria Koleva; Emilia Dimitrova
- Source
- International Journal of Pharmaceutics. 93:21-26
- Subject
- Active ingredient
Aqueous solution
Diffusion
technology, industry, and agriculture
Pharmaceutical Science
Polyvinyl alcohol
Dosage form
Viscosity
chemistry.chemical_compound
Ophthalmic solutions
Hydrophilic polymers
chemistry
Chemical engineering
Organic chemistry
- Language
- ISSN
- 0378-5173
High-molecular weight polyoxyethylene (POE) was evaluated for potential use as an additive in ophthalmic solutions of indomethacin. The basic drug model was formulated on the basis of hydrotropic and micellar interactions. The influence of POE on the solution viscosity and stability, as well as on in vitro diffusion of indomethacin through an artificial lipid membrane, was comparatively studied with other hydrophilic polymers. It was established that POE shows advantages over hydroxypropylmethylcellulose and polyvinyl alcohol and can be used as a polymeric additive in ophthalmic aqueous solutions of indomethacin.