The removal of toluene using a cycling adsorption and plasma mineralization process was investigated in a packed reactor. The supports of catalysts were optimized in regards to mineralization rate (MR), CO2 selectivity (SCO2), and the production of by-products. The hybrid support γ-Al2O3-HY showed a much better MR in comparison to that of HY alone. Using hybrid HY-γ-Al2O3 as supports, loading Ag–Mn on only HY or γ-Al2O3 had a better MR than loading Ag–Mn on both HY and γ-Al2O3. The stability study showed that intermediates accumulated on the surface of the catalyst lead to its deterioration.