Effect of sildenafil (Viagra) on epidermal growth factor expression in submandibular gland of diabetic male rats
- Resource Type
- Authors
- Mohsen A. Moustafa; Abeer Alrefaiy Mohamed; Safaa A. Abdel-Maksoud; Dalia A. Elgamal
- Source
- The Egyptian Journal of Histology. 34:403-414
- Subject
- medicine.medical_specialty
Histology
business.industry
Sildenafil
Growth factor
medicine.medical_treatment
Phosphodiesterase
Disease
medicine.disease
Submandibular gland
chemistry.chemical_compound
Endocrinology
medicine.anatomical_structure
stomatognathic system
chemistry
Epidermal growth factor
Diabetes mellitus
Internal medicine
medicine
Immunohistochemistry
business
hormones, hormone substitutes, and hormone antagonists
- Language
- ISSN
- 1110-0559
BackgroundEpidermal growth factor (EGF) is produced in rodents mainly by the granular convoluted tubules in submandibular glands. EGF deficiency in diabetes mellitus could be implicated in the complications of the disease. Sildenafil (Viagra), one of the phosphodiesterase inhibitors, contributes in