MK-801 alters RGS2 levels and adenylyl cyclase sensitivity in the rat striatum
- Resource Type
- Authors
- Xavier Langlois; Jean-Marc Taymans; Josée E. Leysen; Anne Simone Josephine Lesage; Catarina Cruz
- Source
- Neuroreport, 16(2), 159-162. Lippincott Williams and Wilkins Ltd.
Taymans, J M, Cruz, C, Lesage, A S, Leysen, J E M F & Langlois, X 2005, ' MK-801 alters RGS2 levels and adenylyl cyclase sensitivity in the rat striatum ', Neuroreport, vol. 16, no. 2, pp. 159-162 . https://doi.org/10.1097/00001756-200502080-00018
- Subject
- Male
medicine.medical_specialty
Gs alpha subunit
Forskolin
Dose-Response Relationship, Drug
General Neuroscience
ADCY9
Biology
Corpus Striatum
ADCY10
Rats
Adenylyl cyclase
chemistry.chemical_compound
Endocrinology
Metabotropic receptor
chemistry
Internal medicine
medicine
Animals
Dizocilpine Maleate
Rats, Wistar
RGS Proteins
RGS2
Adenylyl Cyclases
Ionotropic effect
- Language
- English
- ISSN
- 0959-4965
The present report examines the eiects of acute NMDA antagonism on Regulator of G Protein Signaling 2 (RGS2) expression and adenylyl cyclase sensitivity in the rat striatum. MK- 801and phencyclidine rapidly down-regulate RGS2 mRNA. The down-regulation of RGS2 by MK- 801 was dose dependent and transient. Because previous reports showed that RGS2 attenuates activity of adenylyl cyclase, RGS2 protein level and sensitivity of adenylyl cyclase to forskolin was tested 2 h after administration of MK- 801 (1mg/kg). In striatal membranes of these rats, RGS2 protein level was 17% lower and forskolin-stimulated cAMP production 38% higher than in controls. These ¢ndings reveal a cross-talk between NMDA receptors and adenylyl cyclase and suggest a general cross-talk mechanism by which RGS proteins transcriptionally regulated by ionotropic receptors can alter signaling properties of metabotropic receptors. NeuroReport 16:159^162 � c 2005 Lippincott Williams & Wilkins.