Reiterative Chiral Resolution/Racemization/Recycle (RRR Synthesis) for an Effective and Scalable Process for the Enantioselective Synthesis of a Dual IDO1/TDO2 Inhibitor Imidazoisoindole Derivative
- Resource Type
- Authors
- Antonia Di Mola; Dimitri Ippoliti; Cristina Crescenzi; Annunziata Langella; Thomas Fuchss; Diego Rozzi; Antonio Massa
- Source
- Subject
- heterocycles
Organic Chemistry
asymmetric synthesis
Enantioselective synthesis
5H-imidazo[5
anticancer
Combinatorial chemistry
Chiral resolution
chemistry.chemical_compound
chemistry
5H-imidazo[5,1- a]isoindole
chiral resolution
1- a]isoindole
Physical and Theoretical Chemistry
Isoindole
Racemization
Derivative (chemistry)
- Language
- English
Herein, we report an effective and scalable highly enantioselective synthesis of an 5H-imidazo[5,1-a]isoindole derivative via an RRR-synthesis approach (resolution–racemization–recycle). Chiral res...