Abstract 5753: Cancer stem cell markers allow for immune evasion in triple-negative breast cancer
- Resource Type
- Authors
- Andrew D. Hoffmann
- Source
- Cancer Research. 78:5753-5753
- Subject
- Cancer Research
Immune system
Oncology
Cancer stem cell
business.industry
Cancer research
Medicine
Evasion (ethics)
business
Triple-negative breast cancer
- Language
- ISSN
- 1538-7445
0008-5472
Triple-negative breast cancer tumor-initiating cells, or cancer stem cells (CSCs) are identified as a population that is CD44+ and CD24low. These cells are important drivers of distant metastasis and recurrence. An important component of both the recurrence and metastasis functions of CSCs is the capacity to evade immune detection. Our work has identified key members of the antigen presentation machinery required for proper immunosurveillance as being differentially expressed in tumor cells expressing CD44 compared to cells lacking CD44, including a differential response to important immune system cytokines. We are currently working to identify functional differences related to the altered protein levels in these cells. Citation Format: Andrew D. Hoffmann. Cancer stem cell markers allow for immune evasion in triple-negative breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5753.