F-18 FDG PET positive hilar and mediastinal lymphadenopathy mimicking metastatic disease in a melanoma patient treated with interferon-alpha-2b
- Resource Type
- Authors
- George N. Sfakianakis; Dimitrios Kalkanis; Osama Gomaa; Fabio M. Paes; Alexandros Kalkanis
- Source
- Clinical nuclear medicine. 36(2)
- Subject
- Male
medicine.medical_specialty
Mediastinal lymphadenopathy
Alpha interferon
Disease
Malignancy
Diagnosis, Differential
Bronchoscopy
Fluorodeoxyglucose F18
medicine
Mediastinal Diseases
Humans
Radiology, Nuclear Medicine and imaging
Neoplasm Metastasis
Lymphatic Diseases
Melanoma
medicine.diagnostic_test
business.industry
Interferon-alpha
General Medicine
Parotidectomy
Middle Aged
medicine.disease
Positron-Emission Tomography
Lymph
Radiology
Nuclear medicine
business
Tomography, X-Ray Computed
- Language
- ISSN
- 1536-0229
A 49-year-old man with a history of recurrent melanoma in the parotid was treated with parotidectomy, external beam radiation, and high-dose interferon-alpha-2b. Combined F-18 fluorodeoxyglucose positron emission tomography and computed tomography (FDG PET/CT) performed for restaging demonstrated multiple bilateral hilar and mediastinal hypermetabolic foci corresponding to hilar and mediastinal lymphadenopathy. Cytologic specimens obtained by bronchoscopy were negative for malignancy, revealing reactive lymph nodes. Subsequent FDG PET/CT showed regression of the findings. Awareness of possible interferon-associated reaction in melanoma patients who undergo FDG PET is important to avoid pitfalls in the interpretation.