Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNa
Resource Type
Authors
Thilo, Focken ; Sultan, Chowdhury ; Alla, Zenova ; Michael E, Grimwood ; Christine, Chabot ; Tao, Sheng ; Ivan, Hemeon ; Shannon M, Decker ; Michael, Wilson ; Paul, Bichler ; Qi, Jia ; Shaoyi, Sun ; Clint, Young ; Sophia, Lin ; Samuel J, Goodchild ; Noah G, Shuart ; Elaine, Chang ; Zhiwei, Xie ; Bowen, Li ; Kuldip, Khakh ; Girish, Bankar ; Matthew, Waldbrook ; Rainbow, Kwan ; Karen, Nelkenbrecher ; Parisa, Karimi Tari ; Navjot, Chahal ; Luis, Sojo ; C Lee, Robinette ; Andrew D, White ; Chien-An, Chen ; Yi, Zhang ; Jodie, Pang ; Jae H, Chang ; David H, Hackos ; J P, Johnson ; Charles J, Cohen ; Daniel F, Ortwine ; Daniel P, Sutherlin ; Christoph M, Dehnhardt ; Brian S, Safina
Source
Journal of medicinal chemistry . 61(11)
Subject
Voltage-Gated Sodium Channel Blockers Sulfonamides NAV1.7 Voltage-Gated Sodium Channel Molecular Conformation Pain Rats Kinetics Mice Dogs Drug Stability Drug Design Animals Humans Amino Acid Sequence
Language
ISSN
1520-4804