Identification of key regulatory genes connected to NF-κB family of proteins in visceral adipose tissues using gene expression and weighted protein interaction network
- Resource Type
- Authors
- Babajan Banaganapalli; Zuhier Awan; Houda Zrelli; Jamal S. M. Sabir; Muhummadh Khan; Majed Al-Shaeri; Noor Ahmad Shaik; Abdelfatteh El Omri; Naser A. Alkenani; Ramu Elango; Nahid H. Hajrah
- Source
- PLoS ONE, Vol 14, Iss 4, p e0214337 (2019)
PLoS ONE
- Subject
- 0301 basic medicine
Protein family
MAP Kinase Signaling System
Science
Systems biology
Neovascularization, Physiologic
Adipose tissue
Computational biology
Intra-Abdominal Fat
Biology
Phosphatidylinositol 3-Kinases
03 medical and health sciences
Receptors, Glucocorticoid
0302 clinical medicine
Interaction network
Gene expression
Humans
Obesity
Protein Interaction Maps
Gene
Transcription factor
Monomeric GTP-Binding Proteins
Regulator gene
Inflammation
Multidisciplinary
Macrophages
Intracellular Signaling Peptides and Proteins
NF-kappa B
Repressor Proteins
030104 developmental biology
Gene Expression Regulation
030220 oncology & carcinogenesis
Medicine
Proto-Oncogene Proteins c-akt
Research Article
- Language
- ISSN
- 1932-6203
Obesity is connected to the activation of chronic inflammatory pathways in both adipocytes and macrophages located in adipose tissues. The nuclear factor (NF)-κB is a central molecule involved in inflammatory pathways linked to the pathology of different complex metabolic disorders. Investigating the gene expression data in the adipose tissue would potentially unravel disease relevant gene interactions. The present study is aimed at creating a signature molecular network and at prioritizing the potential biomarkers interacting with NF-κB family of proteins in obesity using system biology approaches. The dataset GSE88837 associated with obesity was downloaded from Gene Expression Omnibus (GEO) database. Statistical analysis represented the differential expression of a total of 2650 genes in adipose tissues (p =