ChemInform Abstract: Azadepsipeptides: Synthesis and Evaluation of a Novel Class of Peptidomimetics
- Resource Type
- Authors
- Jürgen Scherkenbeck; and Axel Goehrt; Achim Harder; Daniel Gondol; Hubert Dyker
- Source
- ChemInform. 32
- Subject
- Class (set theory)
Stereochemistry
Chemistry
Antiparasitic
medicine.drug_class
Peptidomimetic
medicine
General Medicine
Combinatorial chemistry
- Language
- ISSN
- 1522-2667
0931-7597
A general route to azadepsipeptides, a new class of pseudopeptides, has been established. The methodology was applied to the synthesis of a bis-aza analogue of the antiparasitic cyclooctadepsipeptide PF1022A. Comparison of the X-ray crystal structures of natural PF1022A (8) and the chimeric aza analogue 9 revealed that the introduction of nitrogen in the backbone of PF1022A results in almost complete conservation of the 3D structure with only minor deviations at the new nitrogen positions.