Fiber membrane with orthogonal aligned surface for guided tissue regeneration
- Resource Type
- Authors
- Hong Li; Rui-peng Chen; Zhenzhao Guo; Yao Ge
- Source
- Materials Letters. 228:301-304
- Subject
- Materials science
Mechanical Engineering
030206 dentistry
02 engineering and technology
021001 nanoscience & nanotechnology
Condensed Matter Physics
Electrospinning
03 medical and health sciences
0302 clinical medicine
Membrane
Mechanics of Materials
Mechanical strength
General Materials Science
Composite material
0210 nano-technology
- Language
- ISSN
- 0167-577X
A novel guided tissue regeneration (GTR) membrane with orthogonal aligned fibers in surface layers and random fibers within interlayer was developed by multilayer electrospinning. The mechanical strength of tri-layer membrane was between random and aligned membranes. The promotion of the proliferations of MC3T3-E1 and NIH-3 T3 cells on the tri-layer membrane were observed during monoculture. When cells were cocultured, the tri-layer membrane was effective in impeding MC3T3-E1 and NIH-3 T3 cell infiltration by guiding cells to grow along the direction of the fiber alignment.