Improved Antibacterial Activity of the Marine Peptide N6 against Intracellular Salmonella Typhimurium by Conjugating with the Cell-Penetrating Peptide Tat
- Resource Type
- Authors
- Zhanzhan, Li; Da, Teng; Ruoyu, Mao; Xiao, Wang; Ya, Hao; Xiumin, Wang; Jianhua, Wang
- Source
- Journal of medicinal chemistry. 61(17)
- Subject
- Salmonella typhimurium
Mice, Inbred ICR
Molecular Structure
Cell-Penetrating Peptides
Microbial Sensitivity Tests
Peritonitis
Anti-Bacterial Agents
Mice
Structure-Activity Relationship
RAW 264.7 Cells
Salmonella Infections
Animals
Female
Antimicrobial Cationic Peptides
- Language
- ISSN
- 1520-4804
The poor penetration ability of antimicrobial agents limits their use in the treatment of intracellular bacteria. In this study, the conjugate CNC (6) was generated by connecting the cell-penetrating peptide Tat