Purpose To compare the plasma immune globulin and complement levels in different sorts of glaucoma to assess its association. Methods Cohort study. Plasma samples were collected from 226 normal controls and 236 glaucoma patients included 92 with acute primary angle-closure glaucoma (APACG), 76 with chronic primary angle-closure glaucoma (CPACG), 68 with primary open-angle glaucoma (POAG). 163 glaucoma patients with high intraocular pressure(IOP) was classified as a subgroup. Six indexes were analyzed: C3, C4, CH50, IgA, IgG, and IgM. Results There was a significant difference in C4, IgA, IgG, and IgM between patients with high IOP and normal controls groups( P Conclusions The levels of the plasma expression of C3, IgA, IgG, IgM may be useful for discriminating the glaucoma patients and for assessing the progress of glaucoma in different sorts.