Removal of organic micropollutants from wastewater represents a challenge for conventional activated sludge systems and advanced biological systems (membrane bioreactors, MBRs). Systems that promote different removal mechanisms (hybrid systems) seem to be a suitable option as they can reduce the level of most organic micropollutants and the impact on the receiving waters. In this context, addition of powdered activated carbon (PAC), either in the biological tank or as a post- treatment is one of the most promising technologies. In the present review 48 selected micropollutants are compared in hybrid MBR where PAC is added in the bioreactor. Increased removal efficiencies are found for most of the compounds in comparison to MBR alone. Adsorption and biodegradation are the main removal mechanisms, depending on the intrinsic properties of each micropollutant, dosage of PAC and concentration of dissolved organic carbon.