Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population-based study from the Swedish AML registry
- Resource Type
- Authors
- Bertil Johansson; Stefan Deneberg; Anders Wahlin; Sören Lehmann; Petar Antunovic; Gunnar Juliusson; Vladimir Lazarevic; Åsa Rangert Derolf; Lovisa Wennström; Martin Höglund; Lars Möllgård; Bertil Uggla; Aldana Rosso
- Source
- European journal of haematology. 98(5)
- Subject
- Adult
Male
Risk
Pediatrics
medicine.medical_specialty
Adolescent
Early death
Trisomy
Gastroenterology
03 medical and health sciences
Young Adult
0302 clinical medicine
Internal medicine
Epidemiology of cancer
medicine
Humans
Registries
In Situ Hybridization, Fluorescence
Aged
Aged, 80 and over
Sweden
Hematology
business.industry
Incidence (epidemiology)
Incidence
Complete remission
Adult Acute Myeloid Leukemia
General Medicine
Middle Aged
medicine.disease
Prognosis
Combined Modality Therapy
Survival Analysis
Population based study
Leukemia, Myeloid, Acute
030220 oncology & carcinogenesis
Population Surveillance
Female
business
030215 immunology
- Language
- ISSN
- 1600-0609
OBJECTIVES AND METHODS: To ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry.RESULTS: Of the 3179 cytogenetically informative AMLs diagnosed January 1997-May 2015, 246 (7.7%) had isolated trisomies. The frequency increased by age (2.4% at age 18-60 years vs. 23% at >60 years; P