T1rho-relaxation in articular cartilage: effects of enzymatic degradation
- Resource Type
- Authors
- Jonathan H. Kaufman; Umamaheswar Duvvuri; Saurabh D. Patel; Ravinder Reddy; J B Kneeland; John S. Leigh
- Source
- Magnetic resonance in medicine. 38(6)
- Subject
- Cartilage, Articular
Magnetic Resonance Spectroscopy
biology
Chemistry
Cartilage
Relaxation (NMR)
Articular cartilage
Anatomy
Osteoarthritis
In Vitro Techniques
medicine.disease
Nuclear magnetic resonance
Degenerative disease
medicine.anatomical_structure
Proteoglycan
Dispersion (optics)
Endopeptidases
medicine
biology.protein
Animals
Radiology, Nuclear Medicine and imaging
Cattle
Proteoglycans
Enzymatic degradation
- Language
- ISSN
- 0740-3194
Spin-lattice relaxation in the rotating frame (T1rho) dispersion spectroscopy and imaging were used to study normal and enzymatically degraded bovine articular cartilage. Normal specimens demonstrate significant T1rho "dispersion" (approximately 60 to approximately 130 ms) in the 100 Hz to 9 kHz frequency range. Proteoglycan-degraded specimens have 33% greater T1rho values than collagen-degraded or normal samples. T1rho-weighted images reveal structure not found in conventional T1- or T2-weighted images. Our results suggest that T1rho measurements are selectively sensitive to proteoglycan content. The potential of this method in distinguishing the early degenerative changes in cartilage associated with osteoarthritis is discussed.