Childhood disruptive behavior disorders (DBD), including oppositional-defiant disorder and conduct disorder, predict risk for persistent antisocial behavior across the lifespan, as well as poor mental and physical health, educational, and socioeconomic outcomes. However, the presence of callous-unemotional (CU) traits identifies a distinct subgroup of children with DBD (i.e., DBD+CU) at risk for severe outcomes, including violence, crime, and substance use, over and above severity of DBD symptoms. CU traits refer to the presence of callous, uncaring, and remorseless behavior, lack of guilt and empathy, and a reduced propensity to offer help or care to other. These features have important implications for prognosis and treatment, as children with CU traits are thought to require targeted and personalized interventions. However, questions remain whether existing treatments for DBDs are efficacious for children with CU traits or whether specific, tailored treatments are needed. The purpose of this meta-analysis is to provide researchers and clinicians with a detailed road map and a useful quantitative summary of the literature on the effectiveness of treatment for children and adolescents with CU traits, and the effectiveness of treatment for reducing CU traits.