Epigenetic regulation of adipogenesis by histone-modifying enzymes
- Resource Type
- Authors
- Paolo Emidio Macchia; Paola Ungaro; Fabiana Franchini; Immacolata Cristina Nettore; Laura Santana-Viera
- Source
- Subject
- Cancer Research
Histone-modifying enzymes
obesity
Biology
Histone Deacetylases
Epigenesis, Genetic
chemistry.chemical_compound
Mice
white adipose tissue
Adipocyte
Genetics
Transcriptional regulation
Animals
Humans
histone modification
Epigenetics
adipogenesi
Epigenomics
Histone Acetyltransferases
Histone Demethylases
Adipogenesis
Mesenchymal stem cell
brown adipose tissue
Chromatin Assembly and Disassembly
Cell biology
Histone Code
Histone
chemistry
biology.protein
Histone Methyltransferases
epigenetic
- Language
- English
Many studies investigating the transcriptional control of adipogenesis have been published so far; recently the research is focusing on the role of epigenetic mechanisms in regulating the process of adipocyte development. Histone-modifying enzymes and the histone tails post-transcriptional modifications catalyzed by them, are fundamentally involved in the epigenetic regulation of adipogenesis. In our review, we will discuss recent advances in epigenomic regulation of adipogenesis with a focus on histone-modifying enzymes implicated in the various phases of adipocytes differentiation process from mesenchymal stem cells to mature adipocytes. Understanding adipogenesis, may provide new ways to treat obesity and related metabolic diseases.