The impact of human single nucleotide polymorphisms on Bacillus Calmette-Guérin responses
- Resource Type
- Authors
- Nigel Curtis; Mihai G. Netea; Nicole L Messina
- Source
- Vaccine, 38, 40, pp. 6224-6235
Vaccine, 38, 6224-6235
- Subject
- Tuberculosis
030231 tropical medicine
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
Mycobacterium tuberculosis
03 medical and health sciences
0302 clinical medicine
Genetic variation
medicine
Humans
030212 general & internal medicine
Genetic variability
Tuberculosis Vaccines
Mycobacterium bovis
General Veterinary
General Immunology and Microbiology
biology
Public Health, Environmental and Occupational Health
biology.organism_classification
medicine.disease
Infectious Diseases
Immunology
BCG Vaccine
Molecular Medicine
Tuberculosis vaccines
BCG vaccine
- Language
- ISSN
- 1873-2518
0264-410X
Item does not contain fulltext The influence of genetic variability on human immune responses has major implications for the understanding of disease mechanisms and host-pathogen interactions. Bacillus Calmette-Guérin (BCG) vaccine, which is given globally to protect against tuberculosis, has high variability in its protective efficacy against mycobacteria and its beneficial off-target (heterologous) effects. Single nucleotide polymorphisms (SNPs) are major cause of genetic variation and have been strongly associated with susceptibility to tuberculosis and outcomes following BCG immunotherapy for cancer. This review discusses the contribution of SNPs to the variability in mycobacterial-specific and off-target BCG responses, and the implications for this on development of novel TB vaccines and strategies to harness the beneficial off-target effects of BCG.