Background. Previous studies have demonstrated that once-weekly yoga classes are effective for chronic low back pain (cLBP) in white adults with high socioeconomic status. The comparative effectiveness of twice-weekly classes and generalizability to racially diverse low income populations are unknown.Methods. We conducted a 12-week randomized, parallel-group, dosing trial for 95 adults recruited from an urban safety-net hospital and five community health centers comparing once-weekly (n=49) versus twice-weekly (n=46) standardized yoga classes supplemented by home practice. Primary outcomes were change from baseline to 12 weeks in pain (11-point scale) and back-related function (23-point modified Roland-Morris Disability Questionnaire).Results. 82% of participants were nonwhite; 77% had annual household incomes P<0.001). However, there were no differences between once-weekly and twice-weekly groups for pain reduction [-2.1(95% CI-2.9,-1.3) versus −2.4 (95% CI-3.1,-1.8),P=0.62] or back-related function [-5.1(95% CI-7.0,-3.2) versus −4.9 (95% CI-6.5,-3.3),P=0.83].Conclusions. Twelve weeks of once-weekly or twice-weekly yoga classes were similarly effective for predominantly low income minority adults with moderate to severe chronic low back pain. This trial is registered with ClinicalTrials.govNCT01761617.