Prostate Cancer Diffusion-Weighted Magnetic Resonance Imaging: Does the Choice of Diffusion-Weighting Level Matter?
- Resource Type
- Authors
- Jonas Wallström; Fredrik Langkilde; Jens Johansson; Mikael Hellström; Stefan Kuczera; Jonas Hugosson; Stephan E. Maier
- Source
- Journal of magnetic resonance imaging : JMRIReferences. 55(3)
- Subject
- Male
Reproducibility
Magnetic Resonance Spectroscopy
medicine.diagnostic_test
business.industry
Prostatic Neoplasms
Reproducibility of Results
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
Prostate cancer
medicine.anatomical_structure
Diffusion Magnetic Resonance Imaging
Prostate
medicine
Kurtosis
Biomarker (medicine)
Effective diffusion coefficient
Humans
Radiology, Nuclear Medicine and imaging
Stage (cooking)
business
Nuclear medicine
Retrospective Studies
- Language
- ISSN
- 1522-2586
BACKGROUND Diffusion-weighted magnetic resonance imaging plays an important role in multiparametric assessment of prostate lesions. The derived apparent diffusion coefficient (ADC) could be a useful quantitative biomarker for malignant growth, but lacks acceptance because of low reproducibility. PURPOSE To investigate the impact of the choice of diffusion-weighting levels (b-values) on contrast-to-noise ratio and quantitative measures in prostate diffusion-weighted MRI. STUDY TYPE Retrospective and simulation based on published data. SUBJECTS Patient cohort (21 men with Prostate Imaging-Reporting and Data System (PI-RADS) version 2 score ≥3) from a single-center study. FIELD STRENGTH/SEQUENCE 3 T/diffusion-weighted imaging with single-shot echo-planar imaging. ASSESSMENT Both clinical data and simulations based on previously acquired data were used to quantify the influence of b-value choice in normal peripheral zone (PZ) and PZ tumor lesions. For clinical data, ADC was determined for different combinations of b-values. Contrast-to-noise ratio and quantitative diffusion measures were simulated for a wide range of b-values. STATISTICAL TESTS Tissue ADC and the lesion-to-normal tissue ADC ratios of different b-value combinations were compared with paired two-tailed Student's t-tests. A P-value