Novel Positron Emission Tomography Tracers for Imaging Vascular Inflammation
- Resource Type
- Authors
- Jason M. Tarkin; Andrej Ćorović; Christopher Wall; Justin C. Mason; James H.F. Rudd
- Source
- Current Cardiology Reports
- Subject
- ATHEROSCLEROTIC PLAQUE INFLAMMATION
Pathology
medicine.medical_specialty
Cardiac & Cardiovascular Systems
Molecular imaging
030204 cardiovascular system & hematology
030218 nuclear medicine & medical imaging
Disease activity
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
Non-invasive imaging
IMPROVES PREDICTION
Medicine
Humans
Pet tracer
1102 Cardiorespiratory Medicine and Haematology
Large-vessel vasculitis
Inflammation
Science & Technology
medicine.diagnostic_test
business.industry
Vascular inflammation
Topical Collection on Nuclear Cardiology
Coronary vasculature
Pet imaging
Atherosclerosis
RECEPTOR 4 EXPRESSION
3. Good health
Nuclear Cardiology (V Dilsizian, Section Editor)
FDG UPTAKE
PET
Cardiovascular System & Hematology
Underlying disease
Positron emission tomography
Positron-Emission Tomography
Cardiovascular System & Cardiology
RISK-FACTORS
LARGE VESSEL VASCULITIS
TARGETING P-SELECTIN
Radiopharmaceuticals
NONINVASIVE ASSESSMENT
MACROPHAGE
Cardiology and Cardiovascular Medicine
business
Life Sciences & Biomedicine
- Language
Purpose of Review To provide a focused update on recent advances in positron emission tomography (PET) imaging in vascular inflammatory diseases and consider future directions in the field. Recent Findings While PET imaging with 18F-fluorodeoxyglucose (FDG) can provide a useful marker of disease activity in several vascular inflammatory diseases, including atherosclerosis and large-vessel vasculitis, this tracer lacks inflammatory cell specificity and is not a practical solution for imaging the coronary vasculature because of avid background myocardial signal. To overcome these limitations, research is ongoing to identify novel PET tracers that can more accurately track individual components of vascular immune responses. Use of these novel PET tracers could lead to a better understanding of underlying disease mechanisms and help inform the identification and stratification of patients for newly emerging immune-modulatory therapies. Summary Future research is needed to realise the true clinical translational value of PET imaging in vascular inflammatory diseases.