Modified approach to fibrinogen replacement in the setting of dysfibrinogenaemia
- Resource Type
- Authors
- Parveen Bahel; Richard Torres; Henry M. Rinder; Jocelyn B. Chandler; Alexa J. Siddon; Christopher A. Tormey
- Source
- Journal of Clinical Pathology. 72:177-180
- Subject
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Serial dilution
Thrombin Time
Urology
Thrombin time
Fibrinogen
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Dysfibrinogenaemia
Dosing
Dysfibrinogenemia
Child
medicine.diagnostic_test
business.industry
General Medicine
Mixing study
Afibrinogenemia
medicine.disease
030104 developmental biology
Child, Preschool
030220 oncology & carcinogenesis
Cryoprecipitate
Female
business
medicine.drug
- Language
- ISSN
- 1472-4146
0021-9746
Most fibrinogen replacement strategies focus on quantitative deficiencies. A thrombin time (TT) mixing study helped to assess qualitative defects caused by dysfibrinogens. Plasma samples were collected from non-anticoagulated subjects (n=6) meeting laboratory criteria for suspected dysfibrinogenaemia (TT > 22 s; fibrinogen activity