Thermodynamic profiling for fragment-based lead discovery and optimization
- Resource Type
- Authors
- György G. Ferenczy; György M. Keserű
- Source
- Expert opinion on drug discovery. 15(1)
- Subject
- 0303 health sciences
Binding free energy
Chemistry
Fragment-based lead discovery
Proteins
Computational biology
Ligands
03 medical and health sciences
0302 clinical medicine
030220 oncology & carcinogenesis
Drug Discovery
Profiling (information science)
Thermodynamics
030304 developmental biology
Protein Binding
- Language
- ISSN
- 1746-045X
Introduction: The enthalpic and entropic components of the ligand–protein binding free energy reflect the type and quality of the interactions and relate to the physicochemical properties of the li...