Perillyl alcohol alleviates amyloid-β peptides-induced mitochondrial dysfunction and cytotoxicity in SH-SY5Y cells
- Resource Type
- Authors
- Rizwan Ullah; Mohammad Mobarak Hossain; Ehraz Anis; Fakiha Firdaus; Mohammad Faraz Zafeer; Mohd. Waseem; Faraz Ahmad; Asif Ali
- Source
- International Journal of Biological Macromolecules. 109:1029-1038
- Subject
- 0301 basic medicine
Programmed cell death
SH-SY5Y
Cell Survival
Amyloid beta
Apoptosis
DNA Fragmentation
Pharmacology
Mitochondrial Membrane Transport Proteins
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Structural Biology
Cell Line, Tumor
medicine
Humans
Dementia
Cytotoxicity
Molecular Biology
Membrane Potential, Mitochondrial
Amyloid beta-Peptides
biology
Mitochondrial Permeability Transition Pore
MPTP
Perillyl alcohol
Cytochromes c
Drug Synergism
General Medicine
medicine.disease
Mitochondria
030104 developmental biology
chemistry
Mitochondrial permeability transition pore
Monoterpenes
biology.protein
Reactive Oxygen Species
Ion Channel Gating
030217 neurology & neurosurgery
- Language
- ISSN
- 0141-8130
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common type of dementia in elderly ( >65 years of age). Excessive extra cellular deposits of amyloid beta (Aβ) are a pathological feature of AD. Aβ can cause cell death through oxidative damage; recent studies have implicated opening of mPTP as a detrimental event in AD-related mitochondrial dysfunctions. Over the past few years, natural compounds with antioxidant properties have shown promise for intervention in AD.